Lupus and medications

I have been taking plaquenil for my lupus, I also have fibromyalgia and osteoarthritis for that I spent years taking celebrex until it caused me to have chronic gastritis, which has really added to my misery, so my doctor decided that I would benefit from injecting methotrexate and discontinuing the celebrex. I injected for the first time the other night and everything seemed fine but about an hour later i got a sore throat and bad headache which lasted about an hour, after that passed i started to develop a itchy rash which drove me nuts for the rest of the night the next morning I was fine, so my question is will this get better the longer I inject this medication? I would like to hear from anyone else who uses methotrexate. thanks, LostHiker59

Hello LostHiker,

I've never taken methotrexate been refused it several times because of my organs but we have quite a few members who are on it and who will answer in due course.

I really do hope yur symptoms ease and give you some relief.

Hugs Terri xxx

Thanks for responding, I appreciate the kind words and hope your feeling well. Have a good weekend. LostHiker

Tez_20 said:

Hello LostHiker,

I've never taken methotrexate been refused it several times because of my organs but we have quite a few members who are on it and who will answer in due course.

I really do hope yur symptoms ease and give you some relief.

Hugs Terri xxx

Hello LostHiker,

Apparentley Methotrexate is similar to plaquenil with side affects but can affect the organs but mainly the liver this is why i was refused having a tumour on my liver plus you have to have your bloods taken regular to see how it's responding with your system.

It's similar to a drug i was taking called Dapsone for SLE which methotrexate is for and the dapsone started turning me yellow after nearly 3mths and i was pulled off it through my organs rejecting it but i do hope someone responds soon.

Also have a nice pleasant weekend yourself.

Love Terri :)

Hello LostHiker, and welcome to the group. You will find information, experience, and support here and I hope more responses to your question, as I take Methotrexate, but the oral form. My doc told me that if this form gave me a lot of nausea and/or vomiting he would recommend the injection. I have had some nausea and occasional vomiting, but I've also been on a long stretch of antibiotic, so it's gonna be difficult to say which is causing this until I finish the antibiotics....if I ever do...lol I wanted to see if you have noticed any changes in your symptoms as I was concerned when I saw that you developed the rash. I think the side-effects from these meds are as difficult to contend with as the disease itself at times....well, close to it anyway. I mean we're injecting or swallowing these chemicals and introducing then into our system and God knows what will happen after we take them, sometimes immediately or sometimes after they build up in our system. Sad that we must put our bodies through this to get relief, but were not left with many options.....I truly hope you can find some answers to your question soon. Keep us posted on how you are doing and ....glad to meet you.

Hi Gail,

Thanks for the imput to help LostHiker :) xxx

Angel312 said:

Hello LostHiker, and welcome to the group. You will find information, experience, and support here and I hope more responses to your question, as I take Methotrexate, but the oral form. My doc told me that if this form gave me a lot of nausea and/or vomiting he would recommend the injection. I have had some nausea and occasional vomiting, but I've also been on a long stretch of antibiotic, so it's gonna be difficult to say which is causing this until I finish the antibiotics....if I ever do...lol I wanted to see if you have noticed any changes in your symptoms as I was concerned when I saw that you developed the rash. I think the side-effects from these meds are as difficult to contend with as the disease itself at times....well, close to it anyway. I mean we're injecting or swallowing these chemicals and introducing then into our system and God knows what will happen after we take them, sometimes immediately or sometimes after they build up in our system. Sad that we must put our bodies through this to get relief, but were not left with many options.....I truly hope you can find some answers to your question soon. Keep us posted on how you are doing and ....glad to meet you.

I only took Methotrexate for 3 weeks. I used the oral kind. My ALT liver enzymes came back to high, so I am now taking Imuran. I wish you the best luck with it. I am not sure if it was in my head, but I felt better on the Methotrexate

Hi LostHiker,

That is the main problem with methotrexate it can affect the organs and mainly the liver like Jusme as stated...that's why my first rheumo refused it because of me having organ problems.

Love Terri :)